Published on: January 2026
DEVELOPMENT AND CHARACTERIZATION OF NANO-BASED DRUG DELIVERY SYSTEMS FOR POORLY SOLUBLE DRUGS
Sneha R. Pawar Rahul S. More
Dr. Mahesh T. Borse
Shree Lakshmi College of Pharmacy
Article Status
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Abstract
Poor aqueous solubility remains a significant challenge in pharmaceutical development, affecting nearly 40% of marketed drugs and over 70% of new chemical entities. Traditional formulation strategies frequently fail to deliver the desired bioavailability, leading to therapeutic inefficiencies. Nano-based drug delivery systems (NDDS) have emerged as a transformative approach to enhance the solubility, stability, and bioavailability of poorly soluble compounds. This research article comprehensively explores the design, development, and characterization of various NDDS — including nanoparticles, nanocrystals, solid lipid nanoparticles (SLNs), nanostructured lipid carriers (NLCs), nanoemulsions, and polymeric micelles — tailored for poorly water-soluble drugs. Through a detailed literature review, materials and methods, in-depth analysis of characterization techniques, and critical evaluation of outcomes, this article highlights how NDDS can improve drug dissolution, pharmacokinetics, targeted delivery, and therapeutic efficacy. The outcomes demonstrate that nano-formulations significantly enhance solubility and bioavailability compared to traditional formulations. Challenges and limitations such as scale-up, physiological barriers, and regulatory considerations are also examined. Finally, future perspectives on clinical translation pathways are discussed, underscoring the potential of NDDS to revolutionize drug delivery for poorly soluble drugs.
How to Cite this Paper
Pawar, S. R. & More, R. S. (2026). Development and Characterization of Nano-Based Drug Delivery Systems for Poorly Soluble Drugs. International Journal of Creative and Open Research in Engineering and Management, <i>02</i>(01), 1-9. https://doi.org/10.55041/ijcope.v2i1.005
Pawar, Sneha, and Rahul More. "Development and Characterization of Nano-Based Drug Delivery Systems for Poorly Soluble Drugs." International Journal of Creative and Open Research in Engineering and Management, vol. 02, no. 01, 2026, pp. 1-9. doi:https://doi.org/10.55041/ijcope.v2i1.005.
Pawar, Sneha, and Rahul More. "Development and Characterization of Nano-Based Drug Delivery Systems for Poorly Soluble Drugs." International Journal of Creative and Open Research in Engineering and Management 02, no. 01 (2026): 1-9. https://doi.org/https://doi.org/10.55041/ijcope.v2i1.005.
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- •Published on: Jan 26 2026
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