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International Journal of Creative and Open Research in Engineering and Management

A Peer-Reviewed, Open-Access International Journal Supporting Multidisciplinary Research, Digital Publishing Standards, DOI Registration, and Academic Indexing.
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ISSN: 3108-1754 (Online)
Crossref DOI: Available
ISO Certification: 9001:2015
Publication Fee: 599/- INR
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License: CC BY 4.0
Peer Review: Double Blind
Volume 02, Issue 03

Published on: March 2026 2026

FORMULATION AND IN VITRO EVALUATION OF NABUMETONE PULSATILE DRUG DELIVERY

Bhumireddy Lakshmi Prasanna

Department of Pharmaceutics Srinivasa Institute of Pharmaceutical Sciences
DOI:https://doi.org/10.55041/ijcope.v2i3.097

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Abstract

The present study aimed to design and evaluate an oral pulsatile drug delivery system (Pulsincap) for Nabumetone, a nonsteroidal anti-inflammatory drug (NSAID) used in the management of rheumatoid arthritis (RA), osteoarthritis (OA), and juvenile rheumatoid arthritis. The Pulsincap system consists of a water-insoluble hard gelatin capsule body cross-linked with formaldehyde vapors, filled with an optimized Nabumetone tablet blend, and sealed with a hydrogel plug prepared from Ethyl Cellulose and HPMC K15M in varying ratios. Twelve tablet formulations (F1–F12) were prepared using different super-disintegrants (Crospovidone, Ludiflash, Lycoat). Formulation F12 (Lycoat 20 mg) was selected as optimized, showing maximum drug release of 98.16% within 30 minutes. Capsule bodies exposed to formaldehyde for 6 hours maintained the required 6-hour lag time. Among five pulsincap formulations (P1F12–P5F12), P5F12 — containing Ethyl Cellulose:HPMC K15M (2:1) — was identified as optimal, achieving 99.84% drug release after a 6-hour lag time. Drug release followed Korsmeyer-Peppas kinetics with super case-II transport. Stability studies at 40°C/75% RH for 3 months confirmed formulation stability. This system offers a promising chronotherapeutic approach for timed drug delivery aligned with the circadian pattern of arthritic symptoms.

How to Cite this Paper

Prasanna, B. L. (2026). Formulation and in Vitro Evaluation of Nabumetone Pulsatile Drug Delivery. International Journal of Creative and Open Research in Engineering and Management, <i>02</i>(03). https://doi.org/10.55041/ijcope.v2i3.097

Prasanna, Bhumireddy. "Formulation and in Vitro Evaluation of Nabumetone Pulsatile Drug Delivery." International Journal of Creative and Open Research in Engineering and Management, vol. 02, no. 03, 2026, pp. . doi:https://doi.org/10.55041/ijcope.v2i3.097.

Prasanna, Bhumireddy. "Formulation and in Vitro Evaluation of Nabumetone Pulsatile Drug Delivery." International Journal of Creative and Open Research in Engineering and Management 02, no. 03 (2026). https://doi.org/https://doi.org/10.55041/ijcope.v2i3.097.

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  • •Published on: Mar 29 2026
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