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International Journal of Creative and Open Research in Engineering and Management

A Peer-Reviewed, Open-Access International Journal Supporting Multidisciplinary Research, Digital Publishing Standards, DOI Registration, and Academic Indexing.
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ISSN: 3108-1754 (Online)
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ISO Certification: 9001:2015
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License: CC BY 4.0
Peer Review: Double Blind
Volume 02, Issue 04

Published on: April 2026

POTENTIAL THERAPEUTIC ROLE OF CROCETIN IN WESTERN DIET-INDUCED COGNITIVE DYSFUNCTION

Suhail Ahmad Beigh Gulshan Dhiman Aadil Feroz Ritik Raushan Ashirwad Kumar

Subhi Sharma

Department of Pharmacy School Of Pharmacy  Desh Bhagat University Mandigobindgarh Punjab India
DOI:https://doi.org/10.55041/ijcope.v2i4.560

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Abstract

The cognitive dysfunction caused by Western diet is a recent worldwide issue, which is caused by the overconsumption of high-fat, high-sugar, and ultra-processed products and foods. It is a diet that causes a rapid progression of neuroinflammation, oxidative stress, insulin resistance, gut microbiome dysbiosis, and blood-brain barrier dysfunction, which result in synaptic dysfunction and gradual cognitive impairment. Crocetin is an antioxidant, anti-inflammatory, and metabolic-modulating bioactive carotenoid derived from saffron and Gardenia jasminoides is an effective neuroprotective agent. It improves the work of mitochondria, increases the level of brain-derived neurotrophic factor (BDNF), changes PI3K/Akt signaling, and strengthens the gut-brain axis, which leads to a better cognitive resilience.

How to Cite this Paper

Beigh, S. A., Dhiman, G., Feroz, A., Raushan, R. & Kumar, A. (2026). Potential Therapeutic Role of Crocetin in Western Diet-Induced Cognitive Dysfunction. International Journal of Creative and Open Research in Engineering and Management, <i>02</i>(04). https://doi.org/10.55041/ijcope.v2i4.560

Beigh, Suhail, et al.. "Potential Therapeutic Role of Crocetin in Western Diet-Induced Cognitive Dysfunction." International Journal of Creative and Open Research in Engineering and Management, vol. 02, no. 04, 2026, pp. . doi:https://doi.org/10.55041/ijcope.v2i4.560.

Beigh, Suhail,Gulshan Dhiman,Aadil Feroz,Ritik Raushan, and Ashirwad Kumar. "Potential Therapeutic Role of Crocetin in Western Diet-Induced Cognitive Dysfunction." International Journal of Creative and Open Research in Engineering and Management 02, no. 04 (2026). https://doi.org/https://doi.org/10.55041/ijcope.v2i4.560.

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References

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  • •Peer Review Type: Double-Blind Peer Review
  • •Published on: Apr 22 2026
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