Mouth dissolving tablets (MDTs) have gained important attention in recent years as a patient-friendly alternative to conventional oral dosage forms. Many patients, especially pediatrics, geriatrics individuals, and those suffering from swallowing difficulties, often face challenges while taking standard tablets. MDTs help overcome this problem by dissolving rapidly in the mouth without the need for water, thereby improving convenience and compliance. ^(2,6) Paracetamol is a widely used drug for relieving pain and reducing fever, making it a suitable candidate for such a formulation. ⁽¹⁾

The present study focused on developing and evaluating mouth dissolving tablets of paracetamol using different super-disintegrants. Tablets were prepared using the wet granulation method with crospovidone, croscarmellose sodium, and sodium starch glycolate at different concentrations. A novel co-processed excipient containing pregelatinized starch was also explored to enhance tablet performance. The prepared tablets were tested for various quality parameters including hardness, friability, drug content, disintegration time, wetting time, water absorption, and drug release behavior. ^(1,3)

All the formulations showed acceptable physical properties, with good strength and low friability. Drug content was found to be uniform across all batches. It was observed that tablets containing higher concentrations of super-disintegrants disintegrated more rapidly. Among all, formulations with crospovidone and croscarmellose sodium showed the fastest disintegration and better wetting properties. ^(1,7) Dissolution studies revealed that drug release increased with increasing concentration of super-disintegrants, and optimized formulations released more than 95% of the drug within 30 minutes, meeting pharmacopoeial requirements. ^(1,4)