Cam-follower mechanisms are often used in mechanical systems to change rotary motion into reciprocal motion. Nevertheless, wear at the cam-follower interface has a large influence on performance, accuracy, and lifetime. In this research, the impact of kinematic parameters: displacement, velocity, acceleration and jerk on wear in cam-follower systems are examined. Mathematical models for different types of motion are created and their kinematic behaviour is analysed mathematically such as uniform velocity, simple harmonic motion (SHM), cycloidal motion etc. This study relates these parameters with wear based on a theoretical model of the interaction forces and motion sliding. The findings prove that profiles featuring gentler transitions and at lower values of jerk are favourable in reducing impact forces along with wear. As a result of data analyses, the cycloidal motion has been determined to be best among all analysed profiles due to its smooth acceleration and almost jerk-free characteristics. The study highlights the importance of kinematic optimization in improving durability and reliability of cam-follower systems.