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International Journal of Creative and Open Research in Engineering and Management

A Peer-Reviewed, Open-Access International Journal Supporting Multidisciplinary Research, Digital Publishing Standards, DOI Registration, and Academic Indexing.
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ISSN: 3108-1754 (Online)
Crossref DOI: Available
ISO Certification: 9001:2015
Publication Fee: 599/- INR
Compliance: UGC Journal Norms
License: CC BY 4.0
Peer Review: Double Blind
Volume 02, Issue 6

Published on: June 2026

FORMULATION AND EVALUATION OF TEMOZOLOMIDE ORAL SUSPENSION FOR BRAIN TUMOR THERAPY

Ravindra Narwade Prof. Amol Wadhave Prof. Priya Jaware

Dr. Santosh Payghan

Dept. of Pharmaceutics, Rajesh Bhaiyya Tope College of Pharmacy, Chh.Sambhajinagar

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Plagiarism Passed Peer Reviewed Open Access

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Abstract

Temozolomide (TMZ) is an alkylating agent widely used in the treatment of glioblastoma multiform and other malignant brain tumors. However, the commercially available capsule dosage form presents challenges in pediatric, geriatric, and dysphagia patients due to swallowing difficulty and dose inflexibility. The present study aims to develop and evaluate a stable, patient-friendly oral suspension of temozolomide using a Quality-based pharmaceutics approach. A novel citrate-buffered, polymer-stabilized suspension was formulated to enhance chemical stability and dosing accuracy.

Keywords: Temozolomide, Oral suspension, Brain tumor, Glioblastoma, Pediatric formulation, Stability study.

How to Cite this Paper

Narwade, R., Wadhave, A. & Jaware, P. (2026). Formulation and Evaluation of Temozolomide Oral Suspension for Brain Tumor Therapy. International Journal of Creative and Open Research in Engineering and Management, <i>02</i>(6). https://doi.org/10.55041/ijcope.v2i6.280

Narwade, Ravindra, et al.. "Formulation and Evaluation of Temozolomide Oral Suspension for Brain Tumor Therapy." International Journal of Creative and Open Research in Engineering and Management, vol. 02, no. 6, 2026, pp. . doi:https://doi.org/10.55041/ijcope.v2i6.280.

Narwade, Ravindra,Amol Wadhave, and Priya Jaware. "Formulation and Evaluation of Temozolomide Oral Suspension for Brain Tumor Therapy." International Journal of Creative and Open Research in Engineering and Management 02, no. 6 (2026). https://doi.org/https://doi.org/10.55041/ijcope.v2i6.280.

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  • All submissions are screened under plagiarism detection.
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  • Peer Review Type: Double-Blind Peer Review
  • Published on: Jun 22 2026
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