Volume 02, Issue 6
Published on: June 2026
AGAVE GENUS: PHYTOCHEMISTRY, PHARMACOLOGICAL ACTIVITIES, AND WOUND HEALING POTENTIAL
Jofy Francis Deon David
Dr. V. Pushpa Rani
Department of Advanced Zoology and Biotechnology, Loyola College, Chennai, Tamil Nadu,
India,600 034
India,600 034
Article Status
Plagiarism Passed
Peer Reviewed
Open Access
Available Documents
Abstract
The genus Agave (family Asparagaceae), comprising over 200 species of succulent perennial plants native to arid and semi-arid regions of the Americas and cultivated widely across the globe, represents a rich repository of biologically active phytochemicals with diverse pharmacological properties. Agave species are chemically characterized by steroidal saponins, fructooligosaccharides, phenolic acids, flavonoids, alkaloids, and terpenoids, which collectively underpin their reported antioxidant, antimicrobial, anti-inflammatory, anti-diabetic, and wound healing activities. This review consolidates current knowledge on the botany, phytochemistry, and pharmacological significance of the genus Agave, with a particular focus on activities relevant to wound healing, including antioxidant defense, antimicrobial protection, attenuation of chronic inflammation, and promotion of cell migration. We further highlight the emerging role of Agave-derived extracts as green reducing and capping agents in the synthesis of silver nanoparticles (AgNPs), which amplify the inherent bioactivities of the parent plant matrices and offer multifunctional platforms for biomedical applications. Collectively, the evidence positions the Agave genus as a highly promising botanical source for the development of novel wound care therapeutics.
Keywords: Agave; wound healing; phytochemistry; silver nanoparticles; anti-inflammatory; antioxidant; antimicrobial; steroidal saponins
Keywords: Agave; wound healing; phytochemistry; silver nanoparticles; anti-inflammatory; antioxidant; antimicrobial; steroidal saponins
How to Cite this Paper
Francis, J. & David, D. (2026). Agave Genus: Phytochemistry, Pharmacological Activities, and Wound Healing Potential. International Journal of Creative and Open Research in Engineering and Management, <i>02</i>(6). https://doi.org/10.55041/ijcope.v2i6.418
Francis, Jofy, and Deon David. "Agave Genus: Phytochemistry, Pharmacological Activities, and Wound Healing Potential." International Journal of Creative and Open Research in Engineering and Management, vol. 02, no. 6, 2026, pp. . doi:https://doi.org/10.55041/ijcope.v2i6.418.
Francis, Jofy, and Deon David. "Agave Genus: Phytochemistry, Pharmacological Activities, and Wound Healing Potential." International Journal of Creative and Open Research in Engineering and Management 02, no. 6 (2026). https://doi.org/https://doi.org/10.55041/ijcope.v2i6.418.
Search & Index
References
- Aguilar-Guadarrama, A. B., Díaz-Román, M. A., Osorio-García, M., Déciga-Campos, M., & Ríos, M. Y. (2024). Chemical constituents from Agave applanata and its antihyperglycemic, anti-inflammatory, and antimicrobial activities associated with its tissue repair capability. Planta Medica, 90(5), 397–410. https://doi.org/10.1055/a-2270-5527
- Aguilar-Guadarrama, A. B., Díaz-Román, M. A., Osorio-García, M., Déciga-Campos, M., & Ríos, M. Y. (2024). Chemical constituents from Agave applanata and its antihyperglycemic, anti-inflammatory, and antimicrobial activities associated with its tissue repair capability. Planta Medica, 90(5), 397–410. https://doi.org/10.1055/a-2270-5527
- Ahmed, S. F., Mofijur, M., Rafa, N., Chowdhury, A. T., Chowdhury, S., Nahrin, M., Islam, A. B. M. S., & Ong, H. C. (2022). Green approaches in synthesising nanomaterials for environmental nanobioremediation: Technological advancements, applications, benefits and challenges. Environmental Research, 204, Article 111967. https://doi.org/10.1016/j.envres.2021.111967
- Alaabedin, A. A. Z., Majeed, A. M. A., & Hamza, B. H. (2024). Green synthesis of silver nanoparticles and their effect on the skin determined using IR thermography. Kuwait Journal of Science, 51(1), Article 100076. https://doi.org/10.1016/j.kjs.2023.07.002
- Amarowicz, R., & Pegg, R. B. (2019). Natural antioxidants of plant origin. In I. C. F. R. Ferreira & L. Barros (Eds.), Advances in food and nutrition research (Vol. 90, pp. 1–81). Academic Press. https://doi.org/10.1016/bs.afnr.2019.02.011
- Anajwala, C. C., Patel, R. M., Dakhara, S. L., & Jariwala, J. K. (2010). In vitro cytotoxicity study of Agave americana, Strychnos nux-vomica and Areca catechu extracts using MCF-7 cell line. Journal of Advanced Pharmaceutical Technology & Research, 1(2), 245–252. https://doi.org/10.4103/0110-5558.72424
- Angiosperm Phylogeny Group. (2009). An update of the Angiosperm Phylogeny Group classification for the orders and families of flowering plants: APG III. Botanical Journal of the Linnean Society, 161(2), 105–121. https://doi.org/10.1111/j.1095-8339.2009.00996.x
- Bermúdez Bazán, M., Estarrón Espinosa, M., Urías Silvas, J. E., Arrizon Gaviño, J. P., Gschaedler Mathis, A. C., & Castillo Herrera, G. A. (2025). Polyphenols and antioxidants in southwest Mexico agave leaves. Journal of Bioengineering, Technologies and Health, 8(4), 325–332. https://doi.org/10.34178/jbth.v8i4.515
- Bermúdez-Bazán, M., Castillo-Herrera, G. A., Urias-Silvas, J. E., Escobedo-Reyes, A., & Estarrón-Espinosa, M. (2021). Hunting bioactive molecules from the Agave genus: An update on extraction and biological potential. Molecules, 26(22), Article 6789. https://doi.org/10.3390/molecules26226789
- Brekalo Pršo, I., Kocjan, W., Šimić, H., Brumini, G., Pezelj-Ribarić, S., Borčić, J., Ferreri, S., & Miletić Karlović, I. (2007). Tumor necrosis factor-alpha and interleukin 6 in human periapical lesions. Mediators of Inflammation, 2007, Article 38210. https://doi.org/10.1155/2007/38210
Ethical Compliance & Review Process
- •All submissions are screened under plagiarism detection.
- •Review follows editorial policy.
- •Authors retain copyright.
- •Peer Review Type: Double-Blind Peer Review
- •Published on: Jul 01 2026
CCBYNC
This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. You are free to share and adapt this work for non-commercial purposes with proper attribution.