Volume 02, Issue 05
Published on: May 2026
ANTICANCER PROPERTIES OF THEVETIA
Sristy
Dr . Manesh singh
department of Pharmacology
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Plagiarism Passed
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Abstract
Thevetia peruviana (syn. Cascabela thevetia), a plant belonging to the Apocynaceae family, has long been recognized for its dual nature as both a potent poison and a source of traditional medicines. In recent years, scientific interest has shifted towards its significant potential in oncology. This review synthesizes the current body of research on the anticancer properties of T. peruviana. The plant is a rich reservoir of bioactive compounds, most notably cardiac glycosides (cardenolides) such as thevetin, peruvoside, and neriifolin, which are concentrated in the seeds and other plant parts. In addition, various extracts contain significant amounts of phenolic compounds, flavonoids, and other secondary metabolites. Numerous in vitro studies have demonstrated that extracts from the fruit, leaves, seeds, and latex of T. peruviana exhibit potent cytotoxic and antiproliferative activity against a wide spectrum of human cancer cell lines, including those of the breast, colon, lung, prostate, and liver. The primary mechanism of action is attributed to the inhibition of the Na+/K+-ATPase pump by cardiac glycosides, which disrupts cellular ion homeostasis and triggers downstream signaling cascades. These events culminate in the induction of apoptosis, characterized by caspase activation and PARP cleavage, as well as cell cycle arrest, typically at the G2/M phase. This review consolidates the phytochemical profile of T. peruviana, details its cytotoxic efficacy with specific IC50 values, and elucidates the molecular mechanisms underlying its anticancer effects, highlighting its promise as a source for the development of novel chemotherapeutic agents.
How to Cite this Paper
Sristy, (2026). Anticancer Properties of Thevetia. International Journal of Creative and Open Research in Engineering and Management, <i>02</i>(05). https://doi.org/10.55041/ijcope.v2i5.759
Sristy, . "Anticancer Properties of Thevetia." International Journal of Creative and Open Research in Engineering and Management, vol. 02, no. 05, 2026, pp. . doi:https://doi.org/10.55041/ijcope.v2i5.759.
Sristy, . "Anticancer Properties of Thevetia." International Journal of Creative and Open Research in Engineering and Management 02, no. 05 (2026). https://doi.org/https://doi.org/10.55041/ijcope.v2i5.759.
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- •Published on: May 27 2026
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