Published on: April 2026
CRISPR-BASED GENOME EDITING: FROM MOLECULAR MECHANISM TO CLINICAL APPLICATIONS AND FUTURE PROSPECTS
Komalpreet Kaur Gagan Kaushal Navneet
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Abstract
The paper outlines the radically changing role of CRISPR gene-editing technology in conceptualizing and treating various pathological disorders. CRISPR has advanced over the last ten years since its early days of laboratory research through clinical therapeutics, proving the fact that genetic anomalies could be corrected at the locus of their emergence. The current paper clarifies the current uses of CRISPR in various fields, such as hematologic disorders, eye conditions, cancer treatment, liver diseases, myopathies, and viral infections. Case examples like the sickle cell disease and thalassemia have shown how the process of correcting a defective hemoglobin gene can enhance the production of active erythrocytes in patients. Also the extension of CRISPR complexes into an intravascular environment has allowed individuals who are blind due to genetic factors to see black and white images of some visual cues. The article further compares the recent versions of the CRISPR platform, including Base Editing and Prime Editing, which are designed to provide greater nucleotide specificity and minimize cases of double Addressing breaks. These sophisticated modalities operate on the same principles as editorial corrections, allowing the replacement of individual nucleotides or the replacement of predefined regions of the genome. The results emphasize the rapid development of CRISPR as a powerful therapeutic tool that can be used to alleviate a host of inherited and genetic disorders.
How to Cite this Paper
Kaur, K., Kaushal, G. & Navneet, (2026). CRISPR-Based Genome Editing: From Molecular Mechanism to Clinical Applications and Future Prospects. International Journal of Creative and Open Research in Engineering and Management, <i>02</i>(04). https://doi.org/10.55041/ijcope.v2i4.661
Kaur, Komalpreet, et al.. "CRISPR-Based Genome Editing: From Molecular Mechanism to Clinical Applications and Future Prospects." International Journal of Creative and Open Research in Engineering and Management, vol. 02, no. 04, 2026, pp. . doi:https://doi.org/10.55041/ijcope.v2i4.661.
Kaur, Komalpreet,Gagan Kaushal, and Navneet. "CRISPR-Based Genome Editing: From Molecular Mechanism to Clinical Applications and Future Prospects." International Journal of Creative and Open Research in Engineering and Management 02, no. 04 (2026). https://doi.org/https://doi.org/10.55041/ijcope.v2i4.661.
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References
- Yeroshenko, G. A., Klepets, O. V., Perederii, N. O., Vatsenko, A. V., Ulanovska Tsyba, N. A., Riabushko, O. B., & Shevchenko, K. V. (2021). Biological features of the human vital activity.
- Bartlett, F. C. (2025). The mind at work and play. Taylor & Francis.
- MedlinePlus Genetics. (2024). What is a gene? U.S. National Library of Medicine.
- Tebbi, C. K. (2022). Sickle Cell Disease, a Review. Hemato, 3(2), 341-366.
- Bolideei, M., Barzigar, R., Gahrouei, R. B., Mohebbi, E., Haider, K. H., Paul, S., ... & Mehran, M. J. (2025). Applications of gene editing and nanotechnology in stem cell-based therapies for human diseases. Stem Cell Reviews and Reports, 21(4), 905-934.
- Ghosh, S. K., & Chatterjee, T. (2024). Clustered regularly interspaced short palindromic repeats (CRISPR)-associated proteins (Cas)[CRISPR–Cas]: an emerging technique in plant disease detection and management. In Gene editing in plants: CRISPR-Cas and its applications (pp. 589-645). Singapore: Springer Nature Singapore.
- Isaacson, W. (2022). The Code Breaker--Young Readers Edition: Jennifer Doudna and the Race to Understand Our Genetic Code. Simon and Schuster.
- Ferreira, P., & Choupina, A. B. (2022). CRISPR/Cas9 a simple, inexpensive and effective technique for gene editing. Molecular biology reports, 49(7), 7079-7086.
- Li, Q., Bao, Q., Zhao, S., Wu, F., Li, Y., Wang, K., ... & Gao, H. (2026). Advancements in CRISPR-based therapies for ocular pathologies: from disease mechanisms to intervention strategies. Theranostics, 16(1), 156.
- Doudna, J. A., & Charpentier, E. (2014). The new frontier of genome engineering with CRISPR-Cas9. Science, 346(6213), 1258096.
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- •Published on: Apr 24 2026
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