Published on: February 2026
DEVELOPMENT OF GASTRORETENTIVE FLOATING TABLETS FOR SUSTAINED RELEASE OF ANTI DIABETIC DRUG
Mahesh T. Borse Sandeep V. Kulkarni
Dr. Pooja A. Joshi
Shree Lakshmi College of Pharmacy
Article Status
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Abstract
The development of gastroretentive drug delivery systems (GRDDS) has attracted significant interest in pharmaceutical sciences due to their ability to prolong gastric residence time and enhance the bioavailability of drugs with narrow absorption windows. Gastroretentive floating tablets (GFTs) represent a promising approach for sustained delivery of anti‑diabetic drugs, especially those that are primarily absorbed in the stomach or upper small intestine. This research article presents an in‑depth study on the formulation, optimization, and evaluation of gastroretentive floating tablets containing a model anti‑diabetic drug—metformin hydrochloride. The study focuses on polymer selection, floating behavior, in vitro drug release, swelling and erosion characteristics, and kinetic modeling of drug release. A central composite design was employed to optimize the formulation variables, including polymer ratios and gas‑forming agents. The results indicate that the optimized formulation exhibited desirable buoyancy lag time (<2 minutes), total floating time (>12 hours), and sustained release over 12 hours. The swelling index and matrix integrity supported a controlled release mechanism dominated by polymer relaxation and diffusion. Drug release kinetics aligned closely with non‑Fickian diffusion mechanism. Furthermore, stability studies demonstrated formulation robustness under accelerated conditions. The study concludes that gastroretentive floating tablets can significantly improve the performance of sustained release anti‑diabetic therapy, offering potential therapeutic benefits for patient compliance and glycemic control.
How to Cite this Paper
Borse, M. T. & Kulkarni, S. V. (2026). Development of Gastroretentive Floating Tablets for Sustained Release of Anti Diabetic Drug. International Journal of Creative and Open Research in Engineering and Management, <i>02</i>(02), 1-9. https://doi.org/10.55041/ijcope.v2i2.007
Borse, Mahesh, and Sandeep Kulkarni. "Development of Gastroretentive Floating Tablets for Sustained Release of Anti Diabetic Drug." International Journal of Creative and Open Research in Engineering and Management, vol. 02, no. 02, 2026, pp. 1-9. doi:https://doi.org/10.55041/ijcope.v2i2.007.
Borse, Mahesh, and Sandeep Kulkarni. "Development of Gastroretentive Floating Tablets for Sustained Release of Anti Diabetic Drug." International Journal of Creative and Open Research in Engineering and Management 02, no. 02 (2026): 1-9. https://doi.org/https://doi.org/10.55041/ijcope.v2i2.007.
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References
1. Hwang, S.J., Park, H., & Park, K. (2009). Gastric retentive drug delivery systems. Critical Reviews in Therapeutic Drug Carrier Systems, 15(3), 243–284.
2. Singh, B.N., & Kim, K.H. (2000). Floating drug delivery systems: An approach to oral controlled drug delivery via gastric retention. Journal of Controlled Release, 63(3), 235–259.
3. Streubel, A., Siepmann, J., & Bodmeier, R. (2006). Floating matrix tablets based on low density foam powder: Effects of formulation and processing parameters on drug release. European Journal of Pharmaceutics and Biopharmaceutics, 62(3), 306–314.
4. Raje, V., & Bhanushali, M. (2011). Design and evaluation of gastroretentive floating tablets of metformin hydrochloride. International Journal of Pharmacy and Pharmaceutical Sciences, 3(2), 313–319.
5. Rouge, N., Buri, P., & Doelker, E. (1996). Drug absorption sites in the gastrointestinal tract and dosage forms for site‑specific delivery. International Journal of Pharmaceutics, 136(1–2), 117–139.
6. Mora-Castaño, G., Millán-Jiménez, M., & Caraballo, I. (2023). Hydrophilic High Drug-Loaded 3D Printed Gastroretentive System with Robust Release Kinetics. Pharmaceutics, 15(3), 842. https://doi.org/10.3390/pharmaceutics15030842
7. Arza, R. A. K., Gonugunta, C. S. R., & Veerareddy, P. R. (2009). Formulation and Evaluation of Swellable and Floating Gastroretentive Ciprofloxacin Hydrochloride Tablets. AAPS PharmSciTech, 10(1), 220–226. https://doi.org/10.1208/s12249-009-9200-y
8. More, S., Gavali, K., Doke, O., & Kasgawade, P. (2018). GASTRORETENTIVE DRUG DELIVERY SYSTEM. Journal of Drug Delivery and Therapeutics, 8(4). https://doi.org/10.22270/jddt.v8i4.1788
9. Chen, Y.-C., Ho, H.-O., Liu, D.-Z., Siow, W.-S., & Sheu, M.-T. (2015). Swelling/Floating Capability and Drug Release Characterizations of Gastroretentive Drug Delivery System Based on a Combination of Hydroxyethyl Cellulose and Sodium Carboxymethyl Cellulose. PLoS ONE, 10(1), e0116914. https://doi.org/10.1371/journal.pone.0116914
10. Jaimini, M., Rana, A., & Tanwar, Y. (2007). Formulation and Evaluation of Famotidine Floating Tablets. Current Drug Delivery, 4(1), 51–55. https://doi.org/10.2174/156720107779314730
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