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International Journal of Creative and Open Research in Engineering and Management

A Peer-Reviewed, Open-Access International Journal Supporting Multidisciplinary Research, Digital Publishing Standards, DOI Registration, and Academic Indexing.
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ISSN: 3108-1754 (Online)
Crossref DOI: Available
ISO Certification: 9001:2015
Publication Fee: 599/- INR
Compliance: UGC Journal Norms
License: CC BY 4.0
Peer Review: Double Blind
Volume 02, Issue 05

Published on: May 2026

ETHNOPHARMACOLOGICAL VALIDATION AND COMPUTATIONAL SCREENING OF MADHYA PRADESH MEDICINAL PLANTS AS MULTI-TARGET HIV-1 INHIBITORS WITH PREDICTED BLOOD-BRAIN BARRIER PERMEABILITY FOR NEURO-HIV THERAPY

Afsana Khatoon

Rimpa Manna

RKDF University Gandhi Nagar Bhopal Madhya Pradesh India
DOI:https://doi.org/10.55041/ijcope.v2i5.339

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Plagiarism Passed Peer Reviewed Open Access

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Abstract

Human Immunodeficiency Virus (HIV) affects 39.9 million people globally, with HIV-associated neurocognitive disorders (HAND) affecting 50-60% of patients due to viral persistence in central nervous system (CNS) reservoirs protected by the blood-brain barrier (BBB). Statistical validation employed Cohen's d effect sizes, 95% confidence intervals, and power analysis. Hydrogen bonding with catalytic residues (Asp110, Lys103 for RT; Asp25, Asp29 for PR). The integration of rigorous statistical validation (effect sizes >1.8, power >0.95) with computational pharmacology provides a reproducible framework for bioprospecting traditional medicines.

Keywords: HIV-1; Neuro-HIV; Molecular Docking; Blood-Brain Barrier; Ethnopharmacology; Phytochemicals; Curcuma longa; Computational Pharmacology; Madhya Pradesh; Molecular Dynamics

How to Cite this Paper

Khatoon, A. (2026). Ethnopharmacological Validation and Computational Screening of Madhya Pradesh Medicinal Plants as Multi-Target HIV-1 Inhibitors with Predicted Blood-Brain Barrier Permeability for Neuro-HIV Therapy. International Journal of Creative and Open Research in Engineering and Management, <i>02</i>(05). https://doi.org/10.55041/ijcope.v2i5.339

Khatoon, Afsana. "Ethnopharmacological Validation and Computational Screening of Madhya Pradesh Medicinal Plants as Multi-Target HIV-1 Inhibitors with Predicted Blood-Brain Barrier Permeability for Neuro-HIV Therapy." International Journal of Creative and Open Research in Engineering and Management, vol. 02, no. 05, 2026, pp. . doi:https://doi.org/10.55041/ijcope.v2i5.339.

Khatoon, Afsana. "Ethnopharmacological Validation and Computational Screening of Madhya Pradesh Medicinal Plants as Multi-Target HIV-1 Inhibitors with Predicted Blood-Brain Barrier Permeability for Neuro-HIV Therapy." International Journal of Creative and Open Research in Engineering and Management 02, no. 05 (2026). https://doi.org/https://doi.org/10.55041/ijcope.v2i5.339.

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References


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  • •All submissions are screened under plagiarism detection.
  • •Review follows editorial policy.
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  • •Peer Review Type: Double-Blind Peer Review
  • •Published on: May 12 2026
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