Evaluation of the Antihypertensive Properties of Curcuma Longa (Turmeric)

Raj, Supriya; kumar, shankul

doi:https://doi.org/10.55041/ijcope.v2i5.757

Volume 02, Issue 05

Published on: May 2026

EVALUATION OF THE ANTIHYPERTENSIVE PROPERTIES OF CURCUMA LONGA (TURMERIC)

Supriya Raj shankul kumar

DOI:https://doi.org/10.55041/ijcope.v2i5.757

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Abstract

Elevated arterial blood pressure stands among the foremost contributors to global cardiovascular morbidity, affecting well over one billion adults worldwide. Pharmacological management, while effective, is accompanied by tolerability issues that frequently undermine long-term patient adherence. Against this backdrop, Curcuma longa L. — the rhizomatous spice plant widely known as turmeric — has attracted sustained scientific inquiry owing to its rich curcuminoid content and its centuries-long role in South and Southeast Asian healing traditions. This review consolidates findings from in vitro investigations, controlled animal experiments, and published human trials to construct a coherent picture of how turmeric-derived constituents, particularly curcumin, may favourably modulate blood pressure. The mechanistic canvas is broad: curcumin stimulates endothelial nitric oxide synthase (eNOS), competitively inhibits angiotensin-converting enzyme (ACE), suppresses nuclear factor kappa-B (NF-κB)-driven vascular inflammation, activates the Nrf2 antioxidant axis, antagonises voltage-gated calcium channels in vascular smooth muscle, and attenuates multiple steps within the renin-angiotensin-aldosterone cascade. Clinical meta-analyses report modest yet meaningful reductions in systolic and diastolic pressure, with more pronounced effects in individuals carrying concurrent metabolic burdens. Oral bioavailability of native curcumin remains the central translational obstacle, though phospholipid, nanoparticulate, and micellar delivery platforms have substantially narrowed this gap. We conclude that curcumin warrants further evaluation as a safe adjunctive option in cardiovascular risk management, contingent on rigorously designed, large-scale randomised trials.

Keywords: Curcuma longa; curcumin; hypertension; antihypertensive; nitric oxide; renin-

angiotensin system; oxidative stress; vascular pharmacology; herbal medicine

How to Cite this Paper

Raj, S. & kumar, S. (2026). Evaluation of the Antihypertensive Properties of Curcuma Longa (Turmeric). International Journal of Creative and Open Research in Engineering and Management, <i>02</i>(05). https://doi.org/10.55041/ijcope.v2i5.757

Raj, Supriya, and shankul kumar. "Evaluation of the Antihypertensive Properties of Curcuma Longa (Turmeric)." International Journal of Creative and Open Research in Engineering and Management, vol. 02, no. 05, 2026, pp. . doi:https://doi.org/10.55041/ijcope.v2i5.757.

Raj, Supriya, and shankul kumar. "Evaluation of the Antihypertensive Properties of Curcuma Longa (Turmeric)." International Journal of Creative and Open Research in Engineering and Management 02, no. 05 (2026). https://doi.org/https://doi.org/10.55041/ijcope.v2i5.757.

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•Published on: May 27 2026

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