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International Journal of Creative and Open Research in Engineering and Management

A Peer-Reviewed, Open-Access International Journal Supporting Multidisciplinary Research, Digital Publishing Standards, DOI Registration, and Academic Indexing.
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ISSN: 3108-1754 (Online)
Crossref DOI: Available
ISO Certification: 9001:2015
Publication Fee: 599/- INR
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License: CC BY 4.0
Peer Review: Double Blind
Volume 02, Issue 10

Published on: October 2026

EXPLAINABLE ARTIFICIAL INTELLIGENCE IN HEALTHCARE: METHODS, BENEFITS, AND CHALLENGES FOR TRUSTWORTHY CLINICAL DECISION SUPPORT

Unnati Mehta

M.Sc. Artificial Intelligence

Kandivali Education Society’s B.K Shroff college of Arts and M.H Shroff college of commerce(Autonomous)

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Plagiarism Passed Peer Reviewed Open Access

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Abstract

Artificial intelligence (AI) systems are increasingly studied for tasks such as medical-image analysis, risk prediction, and clinical decision support. However, strong predictive performance does not by itself show why a model reached a particular conclusion or whether that conclusion is appropriate for a patient. This paper reviews explainable artificial intelligence (XAI) methods that can make healthcare predictions more understandable to clinicians and other stakeholders. A focused narrative review was conducted using foundational work on local explanations and Shapley-value-based feature attribution, a healthcare-focused review, and World Health Organization guidance on AI ethics. The paper compares model-specific and model-agnostic explanations, with particular attention to LIME, SHAP, and visual explanation methods. The review indicates that explanations can support error analysis, communication, and model auditing, but they should not be treated as proof that a prediction is correct, fair, or clinically safe. Explanation quality depends on data quality, model behaviour, the intended user, and the clinical context. The paper proposes a practical evaluation framework combining predictive performance, explanation fidelity, stability, clinical usefulness, fairness checks, and human oversight. It concludes that XAI should be integrated into the full lifecycle of clinical AI systems rather than added only after model development.

Index Terms—Explainable AI, healthcare, clinical decision support, interpretability, SHAP, LIME.

How to Cite this Paper

Mehta, U. (2026). Explainable Artificial Intelligence in Healthcare: Methods, Benefits, and Challenges for Trustworthy Clinical Decision Support. International Journal of Creative and Open Research in Engineering and Management, <i>02</i>(10), 1-9. https://doi.org/10.55041/ijcope.v2i10.065

Mehta, Unnati. "Explainable Artificial Intelligence in Healthcare: Methods, Benefits, and Challenges for Trustworthy Clinical Decision Support." International Journal of Creative and Open Research in Engineering and Management, vol. 02, no. 10, 2026, pp. 1-9. doi:https://doi.org/10.55041/ijcope.v2i10.065.

Mehta, Unnati. "Explainable Artificial Intelligence in Healthcare: Methods, Benefits, and Challenges for Trustworthy Clinical Decision Support." International Journal of Creative and Open Research in Engineering and Management 02, no. 10 (2026): 1-9. https://doi.org/https://doi.org/10.55041/ijcope.v2i10.065.

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References



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  • •All submissions are screened under plagiarism detection.
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  • •Peer Review Type: Double-Blind Peer Review
  • •Published on: Oct 12 2026
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