Published on: November 2025
FORMULATION AND IN-VITRO EVALUATION OF SUSTAINED-RELEASE MATRIX TABLETS OF ANTIHYPERTENSIVE DRUGS
Sandeep V. Kulkarni Aishwarya R. Patil
Dr. Neha M. Deshpande
Shree Lakshmi College of Pharmacy
Article Status
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Abstract
1. Abstract
The management of hypertension often requires chronic administration of antihypertensive agents, frequently resulting in fluctuating plasma drug levels, poor patient compliance, and increased side effects. Sustained-release (SR) matrix tablets offer a promising strategy to maintain therapeutic drug concentrations while reducing dosing frequency and improving patient adherence. This research article focuses on the formulation development and in-vitro evaluation of sustained-release matrix tablets of selected antihypertensive drugs such as atenolol, metoprolol succinate, and propranolol hydrochloride. Different hydrophilic and hydrophobic polymers (e.g., hydroxypropyl methylcellulose (HPMC), ethyl cellulose (EC), carbopol, and xanthan gum) were employed to control drug release. Tablets were prepared by direct compression and wet granulation methods. The formulations were optimized based on pre-compression and post-compression parameters, in-vitro dissolution studies, release kinetics, and stability tests. The optimized formulations exhibited sustained drug release up to 24 hours following zero-order/first-order kinetics and Higuchi diffusion models, indicating controlled drug delivery. Sustained-release tablets demonstrated improved in-vitro drug release profiles compared to immediate-release formulations, suggesting therapeutic advantages in hypertensive treatment. This study advances the formulation strategies of SR matrix tablets, with potential implications for enhanced therapeutic efficacy and improved patient compliance. The influence of polymer type and concentration on the drug release rate was systematically investigated to identify the optimal matrix composition. In-vitro dissolution profiles revealed that formulations containing higher proportions of hydrophilic polymers exhibited more consistent and prolonged drug release. Stability studies confirmed that the optimized tablets maintained their physical and chemical integrity under accelerated conditions, supporting their suitability for long-term use.
How to Cite this Paper
Kulkarni, S. V. & Patil, A. R. (2025). Formulation and In-Vitro Evaluation of Sustained-Release Matrix Tablets of Antihypertensive Drugs. International Journal of Creative and Open Research in Engineering and Management, <i>01</i>(01), 1-9. https://doi.org/10.55041/ijcope.v1i2.003
Kulkarni, Sandeep, and Aishwarya Patil. "Formulation and In-Vitro Evaluation of Sustained-Release Matrix Tablets of Antihypertensive Drugs." International Journal of Creative and Open Research in Engineering and Management, vol. 01, no. 01, 2025, pp. 1-9. doi:https://doi.org/10.55041/ijcope.v1i2.003.
Kulkarni, Sandeep, and Aishwarya Patil. "Formulation and In-Vitro Evaluation of Sustained-Release Matrix Tablets of Antihypertensive Drugs." International Journal of Creative and Open Research in Engineering and Management 01, no. 01 (2025): 1-9. https://doi.org/https://doi.org/10.55041/ijcope.v1i2.003.
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