Published on: May 2026
TO IMPROVE SOLUBILITY AND DISSOLUTION RATE OF BCS CLASS-II DRUG USING HERBAL INGREDIENT
Kshitija M. Tomar Unmesh M. Joshi
Dr. Hemant Sawarkar, Dr. K. R. Biyani
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Abstract
The present study demonstrates that co-crystallization is a promising method for enhancing the solubility and dissolution rate of poorly water-soluble drugs, specifically Macitentan. Utilizing a range of analytical techniques such as UV-Visible spectroscopy, solubility testing, dissolution profiling, FTIR, DSC, and SEM, the research confirmed that co-crystals formed with Glycyrrhizic acid, Quercetin, and Saponin substantially improved the physicochemical properties of the parent drug. The incorporation of selected herbal excipients proved effective in enhancing the solubility and dissolution rates of this BCS Class II drug. A comparative analysis with conventional formulations underscored the superior performance of herbal-based systems in enhancing dissolution behavior. Furthermore, the natural origins, biocompatibility, biodegradability, and low toxicity of these materials bolster their applicability in pharmaceutical contexts. Overall, the study concludes that co-crystallization with chosen coformers significantly enhances the solubility, dissolution, and structural properties of Macitentan, with Saponin identified as the most effective coformer. Thus, herbal excipients present a viable alternative to traditional methods of solubility enhancement, offering multifunctional properties, a favorable safety profile, and sustainability, making them particularly well-suited for improving the dissolution characteristics of poorly soluble drugs. The findings provide valuable insights for the application of natural excipients in drug delivery and highlight new research opportunities in the development of eco-friendly and patient-compliant pharmaceutical formulations.
How to Cite this Paper
Tomar, K. M. & Joshi, U. M. (2026). To Improve Solubility and Dissolution Rate of BCS Class-II Drug using Herbal Ingredient. International Journal of Creative and Open Research in Engineering and Management, <i>02</i>(05). https://doi.org/10.55041/ijcope.v2i5.269
Tomar, Kshitija, and Unmesh Joshi. "To Improve Solubility and Dissolution Rate of BCS Class-II Drug using Herbal Ingredient." International Journal of Creative and Open Research in Engineering and Management, vol. 02, no. 05, 2026, pp. . doi:https://doi.org/10.55041/ijcope.v2i5.269.
Tomar, Kshitija, and Unmesh Joshi. "To Improve Solubility and Dissolution Rate of BCS Class-II Drug using Herbal Ingredient." International Journal of Creative and Open Research in Engineering and Management 02, no. 05 (2026). https://doi.org/https://doi.org/10.55041/ijcope.v2i5.269.
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- •Published on: May 08 2026
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