Pomegranate (Punica granatum) and Apple (Malus Domestica) cultivation has increased significantly due to its well-recognized medicinal properties and health promoting benefits. In addition to the edible fruit and juice, pomegranate peel and apple peel a major byproducts of the food processing industry is rich in bioactive compounds including phenolic, tannins, and flavonoids compounds. These phytochemical possess strong antioxidant and broad spectrum antibacterial activities. In this study, antibacterial activity was investigated with pomegranate peel and apple peel extracts against pathogens causing urinary tract infections. The Antibacterial activity was evaluated by means of the agar diffusion method. The antibacterial potential of the peel extract was assessed against specific bacterial strains- E. coli and Streptomyces Albus. Punica granatum and Malus domestica extract were prepared using two different organic solvents- Ethanol and Methanol. Both extracts were effective against all bacteria tested, but the pomegranate methanol extract and pomegranate ethanol extract worked the best as compared to apple methanol extract and apple ethanol extract by inhibiting bacterial growth the most. It also exhibits resistance to certain antibiotics, such as Ciprofloxacin. The present study demonstrates that Punica granatum fruit peel extract exhibits significant antibacterial activity against certain pathogenic bacteria.

KEYWORDS: Antibacterial activity, Ciprofloxacin, Phytochemicals, Tannins and Flavonoids.