IJCOPE Journal

UGC Logo DOI / ISO Logo

International Journal of Creative and Open Research in Engineering and Management

A Peer-Reviewed, Open-Access International Journal Supporting Multidisciplinary Research, Digital Publishing Standards, DOI Registration, and Academic Indexing.
Journal Information
ISSN: 3108-1754 (Online)
Crossref DOI: Available
ISO Certification: 9001:2015
Publication Fee: 599/- INR
Compliance: UGC Journal Norms
License: CC BY 4.0
Peer Review: Double Blind
Volume 02, Issue 8

Published on: August 2026

DEVELOPMENT AND CHARACTERIZATION OF FROVATRIPTAN TRANSDERMAL PATCHES

N .Ranjith Kumar K.Pramod M.Rajavardhan Reddy Syed Talha

Venkateshwara institute of Pharmaceutical Sciences, Cherlapally, Nalgonda.
DOI:https://doi.org/10.55041/ijcope.v2i8.152

Article Status

Plagiarism Passed Peer Reviewed Open Access

Available Documents

Download PDF Review Report

Abstract

Transdermal  patches  deliver  the  drug through  the  skin  in  a  controlled  and predetermined manner in order to increase the therapeutic efficacy of drug. Fravotriptan a 2nd generation triptan that has a favorable tolerability profile and patients have reported greater satisfaction. The aim of the present work was to formulate and evaluate transdermal patches of Fravotriptan. For the current study, the transdermal patch containing drug with different ratios of polymeric combinations and varying plasticizer concentration were prepared. The patch was fabricated by solvent casting method. The casting solvents and plasticizers used were ethanol and propylene glycol respectively. The polymers used were HPMC, PVP and EC. The fabricated patches were evaluated for its physicochemical study. From the studies it concluded that F5 (EC and HPMC of 1:4 ratio and plasticizer 2 ml) whose thickness 0.124 mm, weight variation 110 mg, folding endurance 328 times, percentage moisture absorption of 5%, tensile strength of 0.78 kg/cm2, drug content of 90.42 % and in vitro drug release of 96.3 % may be selected as the optimized formulation. The released kinetics of the optimized formulation follows first order. It can be concluded that it is possible to fabricate a transdermal delivery of Fravotriptan for treatment migraine where the patient acceptance and tolerability profile is high.

How to Cite this Paper

Kumar, N. .., K.Pramod, , Reddy, M. & Talha, S. (2026). Development and Characterization of Frovatriptan Transdermal Patches. International Journal of Creative and Open Research in Engineering and Management, <i>02</i>(8), 1-9. https://doi.org/10.55041/ijcope.v2i8.152

Kumar, N, et al.. "Development and Characterization of Frovatriptan Transdermal Patches." International Journal of Creative and Open Research in Engineering and Management, vol. 02, no. 8, 2026, pp. 1-9. doi:https://doi.org/10.55041/ijcope.v2i8.152.

Kumar, N, K.Pramod,M.Rajavardhan Reddy, and Syed Talha. "Development and Characterization of Frovatriptan Transdermal Patches." International Journal of Creative and Open Research in Engineering and Management 02, no. 8 (2026): 1-9. https://doi.org/https://doi.org/10.55041/ijcope.v2i8.152.

Search & Index

Google Scholar Crossref DOI ResearchGate

References


  • Rangasamy M, Prathiban Recent Advance In Novel Drug Delivery System. Int J Res Ayur Pharm. 1(2); 2010: 316-326.

  • Lainez MJ. Fravotriptan in the treatment of Asian J Neuropsy Disea and Treat. 2(3); 2006: 247–259.

  • Pierce M, Neill C, Felker E, Sebree Zelrix: A novel transdermal formulation of sumatriptan. Ame Soci Headache Treat Res. 2(2); 2013: 34-42.

  • Rao NG, Krishna Formulation and in vitro drug release studies of oxiconazole nitrate transdermal patches. IJAPBS. 3(1); 2014: 39-42.

  • Sudan P, Jallepalli VR, Ramu B, Bhongiri B, Kumar SS, Kumar MS, Kumar VR. Evaluation of Antidepressant Activity and Phyto-chemical Screening of Plant Cordia Dichotoma. Chinese Journal of Applied Physiology. 2024 Aug 27:e20240020.

  • S. Nataraj, P.Sivalingachari, K.Alekhya, DEVELOPMENT AND VALIDATION OF A REVERSE PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC METHOD FOR THE ESTIMATION OF GLIMEPIRIDE IN BULK AND DOSAGE FORMS. IJPBS, Jul-Sept 2013; 3(3): 01-06.

  • Naseera K, Sajeeth CI. Formulation, optimization and evaluation of matrix type of transdermal system of simvastatin using permeation enhancers. Int J Curr Pharm Res. 4(2); 2012: 79- 87.

  • Nainar S, Kingston R. Biopharmaceutical classification system in in vitro / in vivo correlation: Concept and development strategies in drug Trop J Pharma Res. 11(2); 2012: 319-329.

  • Ramu B, Saibaba SV. Role of community pharmacist in management of anaemia. Pharm Pharmacol Int J. 2018;6(3):216‒220. DOI: 10.15406/ppij.2018.06.00178.

  • P. Deepika et al. Formulation and evaluation of doxorubicin nanopsonges for targeted drug delivery African J. Biol. Sci. (South Africa) (2024).

Ethical Compliance & Review Process

  • •All submissions are screened under plagiarism detection.
  • •Review follows editorial policy.
  • •Authors retain copyright.
  • •Peer Review Type: Double-Blind Peer Review
  • •Published on: Aug 19 2026
CCBYNC

This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. You are free to share and adapt this work for non-commercial purposes with proper attribution.

View License
Back to Volume 02, Issue 8View All Issues Next Article

← Previous Article

Detection and Management of Diabetic Retinopathy

Next Article →

Development of an AI-Based Statistical Clinical Decision Support Model for Early Detection of High-Risk Patients in Community Nursing
Scroll to Top