IJCOPE Journal

UGC Logo DOI / ISO Logo

International Journal of Creative and Open Research in Engineering and Management

A Peer-Reviewed, Open-Access International Journal Supporting Multidisciplinary Research, Digital Publishing Standards, DOI Registration, and Academic Indexing.
Journal Information
ISSN: 3108-1754 (Online)
Crossref DOI: Available
ISO Certification: 9001:2015
Publication Fee: 599/- INR
Compliance: UGC Journal Norms
License: CC BY 4.0
Peer Review: Double Blind
Volume 02, Issue 6

Published on: June 2026

EXPLAINABLE FEDERATED ARTIFICIAL INTELLIGENCE FOR PRIVACY-PRESERVING PREDICTIVE HEALTHCARE ANALYTICS: A REVIEW OF CLINICAL DECISION SUPPORT SYSTEMS

Shikhar Mathur

Customer Success Partner & Enterprise Architect: Data and AI

Persistent Systems Inc. Pune, Maharashtra

Article Status

Plagiarism Passed Peer Reviewed Open Access

Available Documents

Abstract

Background: The convergence of artificial intelligence (AI), federated learning (FL), and explainability methods (XAI) represents a paradigm shift in clinical decision support systems (CDSS). Healthcare institutions worldwide face the dual challenge of leveraging large-scale patient data for predictive analytics while rigorously protecting individual privacy under evolving regulatory frameworks such as HIPAA, GDPR, and the Clinical AI Framework.

Objective: This systematic review critically examines the integration of explainability frameworks within federated AI architectures deployed for predictive healthcare analytics, focusing on clinical decision support applications published between 2018 and 2025.

Methods: A structured literature search was conducted across PubMed, IEEE Xplore, Scopus, and ACM Digital Library using PRISMA guidelines. A total of 127 primary studies were identified, of which 84 met full inclusion criteria spanning federated learning architectures, XAI techniques (SHAP, LIME, attention mechanisms, counterfactual explanations), differential privacy, and clinical validation studies.

How to Cite this Paper

Mathur, S. (2026). Explainable Federated Artificial Intelligence for Privacy-Preserving Predictive Healthcare Analytics: A Review of Clinical Decision Support Systems. International Journal of Creative and Open Research in Engineering and Management, <i>02</i>(6). https://doi.org/10.55041/ijcope.v2i6.416

Mathur, Shikhar. "Explainable Federated Artificial Intelligence for Privacy-Preserving Predictive Healthcare Analytics: A Review of Clinical Decision Support Systems." International Journal of Creative and Open Research in Engineering and Management, vol. 02, no. 6, 2026, pp. . doi:https://doi.org/10.55041/ijcope.v2i6.416.

Mathur, Shikhar. "Explainable Federated Artificial Intelligence for Privacy-Preserving Predictive Healthcare Analytics: A Review of Clinical Decision Support Systems." International Journal of Creative and Open Research in Engineering and Management 02, no. 6 (2026). https://doi.org/https://doi.org/10.55041/ijcope.v2i6.416.

Search & Index

References

[1] McMahan, H. B., Moore, E., Ramage, D., Hampson, S., & y Arcas, B. A. (2017). Communication-efficient learning of deep networks from decentralized data. Proceedings of the 20th International Conference on Artificial Intelligence and Statistics (AISTATS), 54, 1273–1282.

[2] Sheller, M. J., Edwards, B., Reina, G. A., et al. (2020). Federated learning in medicine: facilitating multi-institutional collaborations without sharing patient data. Scientific Reports, 10(1), 12598.

[3] Lundberg, S. M., & Lee, S.-I. (2017). A unified approach to interpreting model predictions. Advances in Neural Information Processing Systems (NeurIPS), 30.

[4] Ribeiro, M. T., Singh, S., & Guestrin, C. (2016). 'Why should I trust you?': Explaining the predictions of any classifier. Proceedings of the 22nd ACM SIGKDD International Conference on Knowledge Discovery and Data Mining, 1135–1144.

[5] Li, T., Sahu, A. K., Zaheer, M., Sanjabi, M., Smola, A., & Smith, V. (2020). Federated optimization in heterogeneous networks. Proceedings of Machine Learning and Systems (MLSys), 2, 429–450.

[6] Brisimi, T. S., Chen, R., Mela, T., Olshevsky, A., Paschalidis, I. C., & Shi, W. (2018). Federated learning of predictive models from federated Electronic Health Records. International Journal of Medical Informatics, 112, 59–67.

[7] Dayan, I., Roth, H. R., Zhong, A., et al. (2021). Federated learning for predicting clinical outcomes in patients with COVID-19. Nature Medicine, 27(10), 1735–1743.

[8] Linardos, A., Kushibar, K., Walsh, S., et al. (2022). Federated learning for multi-center imaging diagnostics: a simulation study in cardiovascular disease. Scientific Reports, 12(1), 3551.

[9] Rieke, N., Hancox, J., Li, W., et al. (2020). The future of digital health with federated learning. npj Digital Medicine, 3(1), 119.

[10] Chen, I. Y., Szolovits, P., & Ghassemi, M. (2019). Can AI help reduce disparities in general medical and mental health care? AMA Journal of Ethics, 21(2), 167–179.

Ethical Compliance & Review Process

  • All submissions are screened under plagiarism detection.
  • Review follows editorial policy.
  • Authors retain copyright.
  • Peer Review Type: Double-Blind Peer Review
  • Published on: Jul 01 2026
CCBYNC

This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. You are free to share and adapt this work for non-commercial purposes with proper attribution.

View License
Scroll to Top