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International Journal of Creative and Open Research in Engineering and Management

A Peer-Reviewed, Open-Access International Journal Supporting Multidisciplinary Research, Digital Publishing Standards, DOI Registration, and Academic Indexing.
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ISSN: 3108-1754 (Online)
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Volume 02, Issue 7

Published on: July 2026

ROLE OF HONEYBEE VENOM IN TREATMENT OF VARIOUS DISEASES AND DISORDERS

Mounika K Mohanapriya K R. Kanmani C. Kaviya G. V. Madhumitha P. Monika

Dr.R.Thirumurthy

Vivekanandha Pharmacy College-Sankari-Salem,Affiliated To Tamilnadu Dr MGR Medical University Chennai.

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Abstract

Apitherapy is an alternate therapy that relies on the usage of honeybee products, most importantly bee venom for the treatment of many human diseases. Venom can be introduced into the human body by manual injection or by direct bee stings. Bee venom contains several active molecules such as peptides and enzymes that have advantageous potential in treating inflammation and central nervous system diseases, such as Parkinson’s disease, Alzheimer’s disease and sclerosis. Moreover, bee venom has shown promising benefits against different types of cancer as well as anti-viral activity, even against the Arthritis. Many studies described biological activities of bee venom components and launched preclinical trials to improve the potential use of apitoxin and its constituents as the next generation of drugs. The aim of this review is to summarize the main compounds of bee venom, their primary biological properties, mechanisms of action, and their therapeutic values in alternative therapy strategies.

Keywords: Bee venom, apitoxin, apitherapy, Parkinson’s disease, Alzheimer’s disease, sclerosis, arthritis, cancer

How to Cite this Paper

K, M., K, M., Kanmani, R., Kaviya, C., Madhumitha, G. V. & Monika, P. (2026). Role of Honeybee Venom in Treatment of Various Diseases and Disorders. International Journal of Creative and Open Research in Engineering and Management, <i>02</i>(7). https://doi.org/10.55041/ijcope.v2i7.100

K, Mounika, et al.. "Role of Honeybee Venom in Treatment of Various Diseases and Disorders." International Journal of Creative and Open Research in Engineering and Management, vol. 02, no. 7, 2026, pp. . doi:https://doi.org/10.55041/ijcope.v2i7.100.

K, Mounika,Mohanapriya K,R. Kanmani,C. Kaviya,G. Madhumitha, and P. Monika. "Role of Honeybee Venom in Treatment of Various Diseases and Disorders." International Journal of Creative and Open Research in Engineering and Management 02, no. 7 (2026). https://doi.org/https://doi.org/10.55041/ijcope.v2i7.100.

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References


  1. Mizrahi A, Lensky Y. Bee Products: Properties, Applications, and Apitherapy. Tel Aviv: Springer Science & Business Media; (2013). [Google Scholar]

  2. Hoover SE, Ovinge LP. Pollen collection, honey production, and pollination services: managing honey bees in an agricultural setting. J Econ Entomol. (2018) 111:1509–16. 10.1093/jee/toy125[DOI] [PMC free article] [PubMed] [Google Scholar]

  3. Chen J, Guan S-M, Sun W, Fu H. Melittin, the major pain-producing substance of bee venom. Neurosci Bull. (2016) 32:265–72. 10.1007/s12264-016-0024-y[DOI] [PMC free article] [PubMed] [Google Scholar]

  4. Schumacher MJ, Egen NB. Significance of Africanized bees for public health: a review. Arch Intern Med. (1995) 155:2038–43. 10.1001/archinte.155.19.2038[DOI] [PubMed] [Google Scholar]

  5. King TP, Coscia MR, Kochoumian L. Structure-immunogenicity relationship of melittin and its N-terminal truncated analogs. Biochemistry. (1993) 32:3506–10. 10.1021/bi00064a039[DOI] [PubMed] [Google Scholar]

  6. Abd El-Wahed AA, Khalifa SAM, Sheikh BY, Farag MA, Saeed A, Larik FA, et al. Chapter 13–bee venom composition: from Chemistry to biological activity. In Atta-ur-Rahman editor. Studies in Natural Products Chemistry. Oxford: Elsevier; (2017). p. 459–84.[Google Scholar]

  7. Szókán G, Horváth J, Almás M, Saftics G, Palócz A. Liquid chromatographic analysis and separation of polypeptide components from honey bee venoms. J Liq Chromatogr. (1994) 17:3333–49. 10.1080/10826079408013516[DOI] [Google Scholar]

  8. Hossen MS, Shapla UM, Gan SH, Khalil MI. Impact of bee venom enzymes on diseases and immune responses. Molecules. (2016) 22:1–16. 10.3390/molecules22010025[DOI] [PMC free article] [PubMed] [Google Scholar]

  9. Raghuraman H, Chattopadhyay A. Melittin: a membrane-active peptide with diverse functions. Biosci Rep. (2007) 27:189–223. 10.1007/s10540-006-9030-z[DOI] [PubMed] [Google Scholar]

  10. Paull BR, Yunginger JW, Gleich GJ. Melittin: an allergen of honeybee venom. J Allergy Clin Immunol. (1977) 59:334–8. 10.1016/0091-6749(77)90056-2[DOI] [PubMed] [Google Scholar]

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  • Published on: Jul 10 2026
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